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STO-609

CAMKK inhibitor
Catalog No. C17-900


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Catalog No. Pack Size Price (USD)
C17-900-05 5 mg $105
C17-900-25 25 mg $391
C17-900-BULK BULK Contact Us  


Overview:

Selective inhibitor of Ca2+-calmodulin-dependent protein kinase kinase (Ki = 80 and 15 ng/ml for inhibition of CaM-KKalpha and CaM-KKbeta respectively). Binds to the ATP-binding site. Displays >80-fold selectivity over CaMK1, CaMK2, CaMK4, MLCK, PKC, PKA and p42 MAPK. Cell permeable.

References:


1. H Tokumitsu et al. J. Biol. Chem. 2002 277:15813

2. H Tokumitsu et al. J. Biol. Chem. 2003 278:10908


CAS Registry Number:

52029-86-4


Molecular Formula:

C19H10N2O3 ∙ CH3COOH


Appearance:

Yellow powder


Melting Point:

N/A


Molecular Weight:

314.3


Purity:

98% (TLC); NMR (Conforms)


Solubilization:

May be dissolved in: DMSO (10 mg/ml)


Aliases:

7-oxo-7H-benzimidazo[2,1-a]benz[de]isoquinoline-3-carboxylic acid acetate


Storage and Stability:

Store desiccated as supplied at ambient temperature for up to 2 years. Store solutions at -20°C for up to 3 months.


Molecular Structure:



Product Datasheets



There are no related publications available for this product.


RESEARCH AREAS

Cardiovascular Disease, ERK/MAPK Pathway, Neurobiology, PKA/PKC Pathway, Ser/Thr Kinases



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