Catalog No. M33-900
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Selective inhibitor of c-Jun N-terminal kinase (JNK). Reversibly inhibits JNK1,2 and 3 (IC50=40-90 nM) with >300-fold selectivity against related MAP kinases. Anti-inflammatory activity. Inhibits expression of presenilin-1 and Notch signaling in mouse brain. Cell permeable. Active in vivo.
1. BL Bennett et al. Proc. Natl. Acad. Sci. USA. 2001 98:13681
2. M Rahman et al. Brain Res. 2012 1448:117
CAS Registry Number:
>98% (TLC); NMR (Conforms)
May be dissolved in DMSO (22 mg/ml); or Ethanol (2 mg/ml)
1. Anthra [1-9-cd] pyrazol-6(2H)-one
Storage and Stability:
Store as supplied at ambient temperature for up to 2 years. Store solutions at -20oC for up to 3 months.
There are no related publications available for this product.
Cancer, Cardiovascular Disease, Cytoplasmic Tyrosine Kinases, Inflammation, JAK/STAT Pathway