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SP-600125

JNK inhibitor
Catalog No. M33-900


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Catalog No. Pack Size Price (USD)
M33-900-10 10 mg $72
M33-900-50 50 mg $325
M33-900-BULK BULK Contact Us  


Overview:

Selective inhibitor of c-Jun N-terminal kinase (JNK). Reversibly inhibits JNK1,2 and 3 (IC50=40-90 nM) with >300-fold selectivity against related MAP kinases. Anti-inflammatory activity. Inhibits expression of presenilin-1 and Notch signaling in mouse brain. Cell permeable. Active in vivo.

References:


1. BL Bennett et al. Proc. Natl. Acad. Sci. USA. 2001 98:13681

2. M Rahman et al. Brain Res. 2012 1448:117


CAS Registry Number:

129-56-6


Molecular Formula:

C14H8N2O


Appearance:

Yellow powder


Melting Point:

290oC


Molecular Weight:

110.2


Purity:

>98% (TLC); NMR (Conforms)


Solubilization:

May be dissolved in DMSO (22 mg/ml); or Ethanol (2 mg/ml)


Aliases:


1. Anthra [1-9-cd] pyrazol-6(2H)-one

2. 1,9-Pyrazoloanthrone


Storage and Stability:

Store as supplied at ambient temperature for up to 2 years. Store solutions at -20oC for up to 3 months.


Molecular Structure:



Product Datasheets



There are no related publications available for this product.


RESEARCH AREAS

Cancer, Cardiovascular Disease, Cytoplasmic Tyrosine Kinases, Inflammation, JAK/STAT Pathway



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