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SC-514

IKK2 inhibitor
Catalog No. I03-901


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Catalog No. Pack Size Price (USD)
I03-901-10 10 mg $83
I03-901-50 50 mg $336
I03-901-BULK BULK Contact Us  


Overview:

Selective inhibitor of IKKbeta, IC50=11.2 uM. Inhibits transcription of NFkB-dependent genes in an IL-1beta-induced rheumatoid arthritis model (1). Displays anti-inflammatory activity. Reverses the anti-adipogenic effect of PDGF on human preadipocytes (2). Cell permeable and reversible.

References:


1. N Kishore et al. J. Biol. Chem. 2003 278:32861

2. A Gagnon et al. J. Endocrinol. 2009 201:75


CAS Registry Number:

354812-17-2


Molecular Formula:

C9H8N2OS2


Appearance:

Yellow powder


Melting Point:

209-211oC


Molecular Weight:

224.3


Purity:

>98% (TLC; 5% CH3OH in CH2Cl2; Rf=0.27); NMR (Conforms)


Solubilization:

May be dissolved in DMSO (25 mg/ml); Ethanol (2 mg/ml)


Aliases:

5-(Thien-3-yl)-3-aminothiophene-2-carboxamide


Storage and Stability:

Store desiccated as supplied at ambient temperature for up to 1 year. Store solutions at -20oC for up to 3 months.


Molecular Structure:



Product Datasheets



There are no related publications available for this product.


RESEARCH AREAS

AKT/PKB Pathway, Apoptosis/Autophagy, Inflammation, p38 Pathway



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