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SB-202190

p38 MAP kinase inhibitor
Catalog No. M39-900B


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Catalog No. Pack Size Price (USD)
M39-900B-05 5 mg $121
M39-900B-25 25 mg $462
M39-900B-BULK BULK Contact Us  


Overview:

Potent and selective p38 MAP kinase inhibitor acting at the ATP site (1). Selectively inhibits the p38alpha and beta isoforms (IC50= 50 and 100 nM for SAPK2a/p38 and SAPK2b/p38beta2 respectively) (2). Effectively blocks LPS-induced gene expression in monocytes (3). Induces apoptosis (4). Cell permeable.

References:


1. PR Young et al. J. Biol. Chem. 1997 272:12116

2. SP Davies et al. Biochem. J. 2000 351:95

3. CL Manthey et al. J. Leukoc. Biol. 1998 64:409

4. S Nemoto et al. J. Biol. Chem. 1998 273:16415


CAS Registry Number:

152121-30-7


Molecular Formula:

C20H14N3OF


Appearance:

Yellow powder


Melting Point:

277-278oC


Molecular Weight:

331.4


Purity:

>98% (TLC: 10% CH3OH in CH2Cl2, Rf=0.25); NMR (Conforms)


Solubilization:

May be dissolved in DMSO (30mg/ml)


Aliases:

4-[4-(4-Fluorophenyl)-5-(4-pyridinyl)-1H-imidazol-2-yl] phenol


Storage and Stability:

Store desiccated as supplied at -20oC for up to 2 years. Store solutions at -20oC for up to 2 months.


Molecular Structure:



Product Datasheets



There are no related publications available for this product.


RESEARCH AREAS

Angiogenesis, Apoptosis/Autophagy, Cardiovascular Disease, Cellular Stress, Inflammation, Metabolic Disorder, Neurobiology, NfkB Pathway, p38 Pathway, Ser/Thr Kinases



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