Home    >   Kinase Inhibitors

SB-203580

p38 MAP kinase inhibitor
Catalog No. M39-900C


For enquiry on all Kinase Inhibitors email us at orders@signalchem.com


Catalog No. Pack Size Price (USD)
M39-900C-05 5 mg $94
M39-900C-25 25 mg $446
M39-900C-BULK BULK Contact Us  


Overview:

A potent and selective inhibitor of p38 MAP kinase, IC50=50 and 500 nM for p38 and p38beta2 respectively (1). No other kinases (in a panel of 30) were significantly inhibited including p38gamma and delta at 10 uM (2). A potent inhibitor of inflammatory cytokine production (IC50=15-25 mg/kg in mice and rats) in animal models of arthritis, bone resorption, endotoxin shock and immune function (3).

References:


1. A Cuenda et al. FEBS Lett. 1995 364:229

2. SP Davies et al. Biochem. J. 2000 351:95

3. AM Badger et al. J. Pharmacol. Exp. Ther. 1996 279:1453


CAS Registry Number:

152121-47-6


Molecular Formula:

C21H16N3OSF


Appearance:

Off white powder


Melting Point:

245-247oC


Molecular Weight:

377.4


Purity:

>98% (TLC); NMR (Conforms)


Solubilization:

May be dissolved in DMSO (100 mg/ml); or Ethanol (10 mg/ml, warm)


Aliases:

4-(4-fluorophenyl)-2-(4-methylsulfinylphenyl)-5-(4-pyridyl) imidazole


Storage and Stability:

Store desiccated as supplied at -20oC for up to 2 years. Store solutions a -20oC for up to 3 months.


Molecular Structure:



Product Datasheets



There are no related publications available for this product.


RESEARCH AREAS

Angiogenesis, Apoptosis/Autophagy, Cardiovascular Disease, Cellular Stress, Inflammation, Metabolic Disorder, Neurobiology, NfkB Pathway, p38 Pathway, Ser/Thr Kinases



SIGNALCHEM BIOTECH INC.


About

Terms of Service

Privacy Policy

Get the latest resources, updates and offers in your inbox