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Roscovitine

p34/CDC2 inhibitor
Catalog No. C22-901


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Catalog No. Pack Size Price (USD)
C22-901-02 2 mg $83
C22-901-10 10 mg $325
C22-901-BULK BULK Contact Us  


Overview:

Potent and selective inhibitor of cyclin-dependent kinases displaying higher potency and selectivity compared to olomoucine. p34 cdc2 IC50 = 0.2 uM. Also inhibits p33cdk2 and p33cdk5. Anti-angiogenic. Cell permeable.

References:


1. L Meijer et al. Eur. J. Biochem. 1997 243:527

2. J Liebl et al. Angiogenesis 2011 14:281


CAS Registry Number:

186692-46-6


Molecular Formula:

C19H26N6O


Appearance:

White solid


Melting Point:

N/A


Molecular Weight:

354.5


Purity:

>99% (TLC); NMR (Conforms)


Solubilization:

May be dissolved in Ethanol (10mg/ml) or DMSO (10mg/ml, warm)


Aliases:

(R)-2-((6-(benzylamino)-9-isopropyl-9H-purin-2-yl) amino) butan-1-ol


Storage and Stability:

Store desiccated as supplied at -20oC for up to 2 years. Store solutions at -20oC for up to 3 months.


Molecular Structure:



Product Datasheets



There are no related publications available for this product.


RESEARCH AREAS

Cancer, ERK/MAPK Pathway, Inflammation, Invasion/Metastasis, Neurobiology



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