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Rapamycin

mTOR inhibitor
Catalog No. F17-901


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Catalog No. Pack Size Price (USD)
F17-901-20 20 mg $226
F17-901-100 100 mg $633
F17-901-BULK BULK Contact Us  


Overview:

Potent immunosuppressant. The rapamycin-FKBP12 complex binds to and inhibits mTOR (1). Inhibits IL-2-induced activation of p70 S6 kinase (2). Extends lifespan of mice (3). Induces autophagy in a variety of cell lines (4).

References:


1. S Huang et al. Cancer Biol. Ther. 2003 2:222

2. CJ Kuo et al. Nature 1992 358:70

3. DE Harrison et al. Nature 2009 460:392

4. A Flemming et al. Nat. Chem. Biol. 2011 7:9


CAS Registry Number:

53123-88-9


Molecular Formula:

C51H79NO13


Appearance:

White crystalline powder


Melting Point:

N/A


Molecular Weight:

914.2


Purity:

>98% (TLC: 10% CH3OH in CH2Cl2; Rf=0.51); NMR (Conforms)


Solubilization:

Soluble in DMSO (50 mg/ml); or Ethanol (50 mg/ml)


Aliases:

Sirolimus; Fermentation product


Storage and Stability:

Storage, Stability and Shipping


Molecular Structure:



Product Datasheets



There are no related publications available for this product.


RESEARCH AREAS

AKT/PKB Pathway, Angiogenesis, Apoptosis/Autophagy, Cancer, Inflammation, Metabolic Disorder



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