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Alsterpaullone

GSK3beta and CDK5/p25 inhibitor
Catalog No. G09-901C


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Catalog No. Pack Size Price (USD)
G09-901C-01 1 mg $72
G09-901C-05 5 mg $303
G09-901C-BULK BULK Contact Us  


Overview:

A potent and selective inhibitor of GSK-3beta and CDK5/p25. Potent inhibitor of CDK1/Cyclin B (IC50=35 nM) (1). Induces apoptosis (2). Inhibits angiogenesis (3).

References:


1. J Bain et al. Biochem. J. 2003 371:199

2. T Lahusen et al. Mol. Carcinog. 2003 36:183

3. S Zahler et al. Angiogenesis 2010 13:239


CAS Registry Number:

237430-03-4


Molecular Formula:

C16H11N3O3


Appearance:

Brown crystalline powder


Molecular Weight:

293.3


Purity:

>96% (TLC); NMR (Conforms)


Solubilization:

May be dissolved in DMSO (10 mg/ml)


Aliases:

9-Nitro-7,12-dihydroindolo-[3,2-d][1] benzazepin-6(5)-one


Storage and Stability:

Store desiccated as supplied at -20oC for up to 2 years. Store solutions at -20oC for up to 2 months.


Molecular Structure:



Product Datasheets



There are no related publications available for this product.


RESEARCH AREAS

AKT/PKB Pathway, Apoptosis/Autophagy, Cancer, Cardiovascular Disease, Inflammation, Invasion/Metastasis, Metabolic Disorder, Neurobiology, NfkB Pathway, WNT Signaling



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