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AG-1478

EGFR inhibitor
Catalog No. E10-900B


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Catalog No. Pack Size Price (USD)
E10-900B-05 5 mg $121
E10-900B-25 25 mg $473
E10-900B-BULK BULK Contact Us  


Overview:

Potent and selective inhibitor of the EGFR kinase IC50 = 3 nM. Inhibits proliferation of a variety human cancer cell lines (1,2). Reduces pulmonary fibrosis in a rat model (3). Cell permeable.

References:


1. Y Han et al. Cancer. Res.1996 56:3859

2. G Partik et al. J. Cancer Res. Clin. Oncol.1999 125:379

3. AB Rice et al. Am. J. Pathol. 1999 155:213


CAS Registry Number:

175178-82-2


Molecular Formula:

C16H14ClN3O2


Appearance:

Off white powder


Melting Point:

177-178oC


Molecular Weight:

315.8


Purity:

>98% (TLC); NMR (Conforms)


Solubilization:

May be dissolved in DMSO (30 mg/ml); or Ethanol (10 mg/ml, warm)


Aliases:


1. N-(3-Chlorophenyl)-6,7-dimethoxy-4-quinazolinanine

2. Free Base


Storage and Stability:

Store desiccated as supplied at -20oC for up to 2 years. Store solutions at -20oC for up to 2 months.


Molecular Structure:



Product Datasheets



There are no related publications available for this product.


RESEARCH AREAS

AKT/PKB Pathway, Angiogenesis, Apoptosis/Autophagy, Cancer, Cardiovascular Disease, Cell Cycle, ERK/MAPK Pathway, Inflammation, Invasion/Metastasis, Metabolic Disorder, PKA/PKC Pathway, Receptor Tyrosine Kinases



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