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AG-1296

PDGFR Inhibitor
Catalog No. P12-900


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Catalog No. Pack Size Price (USD)
P12-900-05 5 mg $105
P12-900-25 25 mg $369
P12-900-BULK BULK Contact Us  


Overview:

A potent inhibitor of PDGF receptor tyrosine kinase (PDGFRalpha and beta), IC50=1 µM (1). Also inhibits FGF receptor tyrosine kinase (2), c-kit (3) and FLT3 (4) and reverses transformation induced by activated FLT3 (5). Induces apoptosis in a small-cell lung cancer cell line (H526) (3). Cell permeable.

References:


1. M Kovalenko et al. Biochemistry 1997 36:6260

2. F Strutz et al. Kidney Int. 2001 59:579

3. G W Krystal et al. Cancer Res. 1997 57:2203

4. R Grundler et al. Blood 2003 102:646

5. KF Tse et al. Leukemia 2001 15:1001


CAS Registry Number:

146535-11-7


Molecular Formula:

C16H14N2O2


Appearance:

Off white to yellow powder


Melting Point:

N/A


Molecular Weight:

266.3


Purity:

>98% (TLC); NMR (Conforms)


Solubilization:

May be dissolved in DMSO


Aliases:

6,7-Dimethoxy-3-phenylquinoxaline


Storage and Stability:

Store desiccated as supplied at -20oC for up to 2 years. Store solutions at -20oC for up to 2 months.


Molecular Structure:



Product Datasheets



There are no related publications available for this product.


RESEARCH AREAS

AKT/PKB Pathway, Cancer, ERK/MAPK Pathway, Receptor Tyrosine Kinases



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