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AG-879

NGFR inhibitor
Catalog No. N28-909B


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Catalog No. Pack Size Price (USD)
N28-909B-05 5 mg $83
N28-909B-25 25 mg $347
N28-909B-BULK BULK Contact Us  


Overview:

Inhibits NGF receptor tyrosine kinase (TrkA, pp140trk) . Inhibits NGF-induced neurite outgrowth in PC12 cells (1). Displays antitumor activity in a mouse model (2). Blocks the ETK-PAK1 interaction, suppressing RAS-induced PAK1 activation and malignant transformation (3). Cell permeable.

References:


1. M Ohmichi et al. Biochemistry 1993 32:4650

2. M Rende et al. Anticancer Drugs 2006 17:929

3. H He et al. Cancer Biol. Ther. 2004 3:96


CAS Registry Number:

148741-30-4


Molecular Formula:

C18H24N2OS


Appearance:

Yellow powder


Melting Point:

223-224o C


Molecular Weight:

316.5


Purity:

>99% (TLC); NMR (Conforms)


Solubilization:

May be dissolved in DMSO (25mg/ml) or Ethanol (20 mg/ml)


Aliases:

alpha-Cyano-(3,5-di-t-butyl-4-hydroxy)thiocinnamide


Storage and Stability:

Store desiccated as supplied at -20oC for up to 2 years. Store solutions at -20oC for up to 2 months.


Molecular Structure:



Product Datasheets



There are no related publications available for this product.


RESEARCH AREAS

AKT/PKB Pathway, Angiogenesis, Apoptosis/Autophagy, Cancer, Cardiovascular Disease, Cell Cycle, ERK/MAPK Pathway, Inflammation, Invasion/Metastasis, Metabolic Disorder, Neurobiology, PKA/PKC Pathway, Receptor Tyrosine Kinases



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