Catalog No. F11-900C
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A potent and selective inhibitor of VEGFR-1 (IC50=130nM), VEGFR-2 (IC50=23nM) and VEGFR-3 (IC50=18nM). At higher concentrations it inhibits PDGFR (640nM), c-Kit (236nM) and CSF-1R (380nM). Inactive at other kinases such as EGFR, FGFR-1, CDK-1, Tie-2, c-Met, IGF-1R, c-Src and c-Abl (1). X-ray crystal studies on AAL-993 complexed to the catalytic domain of diphosphorylated VEGFR- 2 indicates that it binds to an inactive conformation of the protein (2). Cell permeable and active in vivo. Inhibits VEGF-induced angiogenesis (mouse model) (1).
1. R Bhat et al. J. Biol. Chem. 2003 278: 45937
2. SH Ramirez et al. Am. J. Pathol. 2010 176:881
CAS Registry Number:
Light yellow powder
>98% (TLC); NMR (Conforms)
May be dissolved in DMSO (>25 mg/ml); or Ethanol (15 mg/ml)
Storage and Stability:
Store desiccated as supplied at ambient for up to 2 years. Store solutions at -20°C for up to 2 months.
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Angiogenesis, Cancer, Cell Cycle, Neurobiology