Home    >   Kinase Inhibitors

AAL-993

VEGF inhibitor
Catalog No. F11-900C


For enquiry on all Kinase Inhibitors email us at orders@signalchem.com


Catalog No. Pack Size Price (USD)
F11-900C-05 5 mg $138
F11-900C-25 25 mg $578
F11-900C-BULK BULK Contact Us  


Overview:

A potent and selective inhibitor of VEGFR-1 (IC50=130nM), VEGFR-2 (IC50=23nM) and VEGFR-3 (IC50=18nM). At higher concentrations it inhibits PDGFR (640nM), c-Kit (236nM) and CSF-1R (380nM). Inactive at other kinases such as EGFR, FGFR-1, CDK-1, Tie-2, c-Met, IGF-1R, c-Src and c-Abl (1). X-ray crystal studies on AAL-993 complexed to the catalytic domain of diphosphorylated VEGFR- 2 indicates that it binds to an inactive conformation of the protein (2). Cell permeable and active in vivo. Inhibits VEGF-induced angiogenesis (mouse model) (1).

References:


1. R Bhat et al. J. Biol. Chem. 2003 278: 45937

2. SH Ramirez et al. Am. J. Pathol. 2010 176:881


CAS Registry Number:

269390-77-4


Molecular Formula:

C20H16F3N3O


Appearance:

Light yellow powder


Melting Point:

N/A


Molecular Weight:

371.1


Purity:

>98% (TLC); NMR (Conforms)


Solubilization:

May be dissolved in DMSO (>25 mg/ml); or Ethanol (15 mg/ml)


Aliases:

2-((4-Pyridyl)methyl)amino-N-(3 (trifluoromethyl)phenyl)benzamide


Storage and Stability:

Store desiccated as supplied at ambient for up to 2 years. Store solutions at -20°C for up to 2 months.


Molecular Structure:



Product Datasheets



There are no related publications available for this product.


RESEARCH AREAS

Angiogenesis, Cancer, Cell Cycle, Neurobiology



SIGNALCHEM BIOTECH INC.


About

Terms of Service

Privacy Policy

Get the latest resources, updates and offers in your inbox