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A83-01

ALK inhibitor
Catalog No. A09-900


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Catalog No. Pack Size Price (USD)
A09-900-05 5 mg $94
A09-900-25 25 mg $380
A09-900-BULK BULK Contact Us  


Overview:

Potent and selective ALK4, 5 and 7 inhibitor (1,2). IC50=45, 12, 7.5 nM respectively. Prevents phosphorylation of Smad2/3 and growth inhibition induced by TGFβ (2). Inhibits differentiation of rat induced pluripotent stem cells and increases clonal expansion efficiency (3). Together with AMI-5 enabled Oct4-induced reprogramming of mouse embryonic fibroblasts (4). Active in rat models. Cell permeable

References:


1. J Vogt et al. Cell Signal. 2011 23:1831

2. M Tojo et al. Cancer Sci. 2012 96:791

3. W Li et al. Cell Stem Cell 2009 4:16

4. X Yuan et al. Stem Cells 2011 29:549


CAS Registry Number:

909910-43-6


Molecular Formula:

C25H19N5S


Appearance:

Light Yellow powder


Melting Point:

N/A


Molecular Weight:

421.5


Purity:

>98% (TLC); NMR (Conforms)


Solubilization:

May be dissolved in DMSO (20mg/ml)


Aliases:

3-(6-Methyl-2-pyridinyl)-N-phenyl-4-(4-quinolinyl)-1H-pyrazole-1-carbothioamide


Storage and Stability:

Store desiccated as supplied at -20°C for up to 2 years. Store solutions at -20°C for up to 2 months.


Molecular Structure:



Product Datasheets



RESEARCH AREAS

AKT/PKB Pathway, Angiogenesis, Cancer, Cardiovascular Disease, JAK/STAT Pathway, Neurobiology, Ser/Thr Kinases



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