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GSK3 inhibitor
Catalog No. G08-900


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Catalog No. Pack Size Price (USD)
G08-900-05 5 mg $105
G08-900-25 25 mg $424
G08-900-BULK BULK Contact Us  


Overview:

Potent and selective inhibitor of glycogen synthase kinase-3 (GSK-3) IC50=5 nM (1). The first pharmacological agent shown to maintain self-renewal in human and mouse embryonic stem cells (2) . Promotes proliferation in mammalian cardiomyocytes (2). A potent inhibitor of malignant lymphoid cell proliferation (3).

References:


1. L Meijer et al. Chem. Biol. 2003 10:1255

2. AS Tseng et al. Chem. Biol. 2006 13:957

3. A Chebel et al. Leuk. Lymphoma 2009 50:2049


CAS Registry Number:

667463-62-9


Molecular Formula:

C16H10BrN3O2


Appearance:

Purple powder


Melting Point:

263-265oC


Molecular Weight:

356.2


Purity:

98% (TLC: 5% CH3OH3 in CH2Cl2, Rf=0.43); NMR (Conforms)


Solubilization:

Soluble in DMSO (15 mg/ml); or Ethanol (4 mg/ml, warm)


Aliases:

(2'Z,3'E)-6-Bromoindirubin-3'-oxime


Storage and Stability:

Store desiccated as supplied at -20°C for up to 1 year. Store solutions at -20°C for up to 2 months.


Molecular Structure:



Product Datasheets



There are no related publications available for this product.


RESEARCH AREAS

AKT/PKB Pathway, Apoptosis/Autophagy, Cancer, Cardiovascular Disease, Inflammation, Invasion/Metastasis, Metabolic Disorder, Neurobiology, NfkB Pathway, WNT Signaling



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