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Dimethylsphingosine

Sphingosine kinase inhibitor
Catalog No. S17-900


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Catalog No. Pack Size Price (USD)
S17-900-05 5 mg $72
S17-900-25 25 mg $292
S17-900-BULK BULK Contact Us  


Overview:

A naturally occurring endogenous sphingolipid (1). Inhibits sphingosine kinase (IC50=5 uM) (2). Induces apoptosis in a variety of cell lines (3).

References:


1. Y Igarashi et al J. Biol. Chem. 1990 265:5385

2. Y Yatomi et al Biochemistry 1996 35:626

3. DR Gude et al FASEB J. 2008 22:2629


CAS Registry Number:

119567-63-4


Molecular Formula:

C20H41NO2


Appearance:

White to off white waxy solid or viscous oil


Melting Point:

N/A


Molecular Weight:

327.5


Purity:

>98% (TLC); NMR (Conforms)


Solubilization:

May be dissolved in DMSO (25 mg/ml) or ethanol (25 mg/ml)


Aliases:

(2S,3R,E)-2-(dimethylamino)octadeca-4-ene-1,3,diol


Storage and Stability:

Store desiccated as supplied at -20oC for up to 3 years. Store solutions at -20oC for up to 3 months.


Molecular Structure:



Product Datasheets



There are no related publications available for this product.


RESEARCH AREAS

Angiogenesis, Apoptosis/Autophagy, Cardiovascular Disease, Invasion/Metastasis, Lipid Kinases, Neurobiology, PKA/PKC Pathway



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