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CHIR-99021

GSK3 beta inhibitor
Catalog No. G09-901B


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Catalog No. Pack Size Price (USD)
G09-901B-01 1 mg $50
G09-901B-05 5 mg $182
G09-901B-BULK BULK Contact Us  


Overview:

Potent and selective inhibitor of glycogen synthase kinase-3beta(GSK3beta, IC50 = 5 nM) and GSK3alpha (IC50 = 10 nM) (1). Induces osteoblastogenesis, increases mineralization and inhibits adipogenesis in ST2 cells (2). Promotes replication and survival of pancreatic beta cells (3). Enhances differentiation and reduces proliferation of adult human olfactory epithelium neural precursors (4). Cell permeable and active in vivo.

References:


1. CN Bennett et al. J. Biol. Chem. 2002 277:30998

2. CN Bennett et al. PNAS 2005 102:3324

3. R Mussmann et al. J. Biol. Chem. 2007 282:12030

4. AP Manceur et al. Exp. Cell. Res. 2011 317:2086


CAS Registry Number:

252917-06-9


Molecular Formula:

C22H18Cl2N8


Appearance:

Tan colored powder


Melting Point:

N/A


Molecular Weight:

465.3


Purity:

>98% (TLC); NMR (Conforms)


Solubilization:

May be dissolved in DMSO (25 mg/ml, warm)


Aliases:

6-[[2-[[4-(2,4-Dichlorophenyl)-5-(5-methyl-1H-imidazol-2-yl)-2-pyrimidinyl] amino] ethyl] amino]-3-pyridinecarbonitrile


Storage and Stability:

Store desiccated as supplied at -20oC for up to 2 years. Store solutions at -20oC for up to 3 months


Molecular Structure:



Product Datasheets



There are no related publications available for this product.


RESEARCH AREAS

AKT/PKB Pathway, Apoptosis/Autophagy, Cancer, Cardiovascular Disease, Inflammation, Invasion/Metastasis, Metabolic Disorder, Neurobiology, NfkB Pathway, WNT Signaling



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