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BML-277

CHK2 inhibitor
Catalog No. C48-901


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Catalog No. Pack Size Price (USD)
C48-901-10 10 mg $105
C48-901-50 50 mg $435
C48-901-BULK BULK Contact Us  


Overview:

A highly selective inhibitor of Chk2 (IC50=15 nM). Displays <25% inhibition of 35 other kinases at 10 uM) (1). It possesses potent radioprotective activity and prevents apoptosis of human T-cells subjected to ionizing radiation (EC50= 3-7.6 μM) (1). It is a useful tool for determining the role of Chk2 in cellular signaling (2).

References:


1. K L Arienti et al. J. Med. Chem. 2005 48:1873

2. Y Pereg et al. Mol. Cell. Biol. 2006 26:6819


CAS Registry Number:

516480-79-8


Molecular Formula:

C20H14ClN3O2


Appearance:

Off white solid


Melting Point:

N/A


Molecular Weight:

363.8


Purity:

≥98% (TLC; 1:1 ethylacetate: hexane; Rf=0.17); NMR (Conforms)


Solubilization:

May be dissolved in DMSO (20 mg/ml); or Ethanol (20 mg/ml)


Aliases:


1. 2-(4-(4-chlorophenoxy)phenyl)-1H-benzimidazole-5-carboxamide

2. Chk2 Inhibitor II


Storage and Stability:

Storage, Stability and Shipping


Molecular Structure:



Product Datasheets



There are no related publications available for this product.


RESEARCH AREAS

Cancer, Cell Cycle, Ser/Thr Kinases



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