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BML-259

CDK5/p25 inhibitor
Catalog No. C33-901


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Catalog No. Pack Size Price (USD)
C33-901-05 5 mg $72
C33-901-25 25 mg $259
C33-901-BULK BULK Contact Us  


Overview:

Potent inhibitor of CDK5/p25 (IC50=64 nM). Inhibits CDK2/cyclin E at slightly higher concentration (IC50=98nM) (1). Protects cells against NAC-amyloid-induced cell death (2). Cell permeable.

References:


1. CJ Helal et al. Bioorg. Med. Chem. Lett. 2004 14:5521

2. A Kazmierczak et al. Neurochem. Int. 2011 58:206


CAS Registry Number:

267654-00-2


Molecular Formula:

C14H16N2OS


Appearance:

White powder


Melting Point:

150-152oC


Molecular Weight:

260.4


Purity:

>98% (TLC: 5% CH3OH/CH2Cl2; Rf=0.46); NMR (Conforms)


Solubilization:

May be dissolved in DMSO (>25 mg/ml) or DMF (30 mg/ml)


Aliases:

N-(5-Isopropylthiazol-2-yl) phenylacetamide


Storage and Stability:

Store desiccated as supplied at ambient temperature for up to 2 years. Store solutions at -20oC for up to 2 months.


Molecular Structure:



Product Datasheets



There are no related publications available for this product.


RESEARCH AREAS

Cancer, Cell Cycle, Ser/Thr Kinases



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