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BAY 11-7082

IKK inhibitor
Catalog No. C51-900


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Catalog No. Pack Size Price (USD)
C51-900-10 10 mg $94
C51-900-50 50 mg $369
C51-900-BULK BULK Contact Us  


Overview:

Inhibits cytokine -induced IkB-alpha phosphorylation via inhibition of IkB Kinase. Inhibits IFNalpha production and blocks nuclear translocation of IRF7. Cell permeable.

References:


1. JW Pierce et al. J. Biol.Chem. 1997 272:21096

2. SA Park et al. Cancer Res. 2009 69:2416

3. R Miyamoto et al. Arthritis Res. Ther. 2010 12:R87


CAS Registry Number:

19542-67-7


Molecular Formula:

C10H9NO2S


Appearance:

White powder


Melting Point:

128-130oC


Molecular Weight:

207.3


Purity:

>98% (TLC); NMR (Conforms)


Solubilization:

May be dissolved in DMSO (>25mg/ml) or ethanol (15 mg/ml)


Aliases:

(E)-3-[(4-methylphenylsulfonyl]-2-propenenitrile


Storage and Stability:

Store desiccated as supplied at ambient temperature for up to 2 years. Store solutions at -20oC for up to 3 months


Molecular Structure:



Product Datasheets



RESEARCH AREAS

AKT/PKB Pathway, Apoptosis/Autophagy, Inflammation, p38 Pathway



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