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AR-A014418

GSK3beta inhibitor
Catalog No. G09-901


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Catalog No. Pack Size Price (USD)
G09-901-05 5 mg $105
G09-901-25 25 mg $347
G09-901-BULK BULK Contact Us  


Overview:

Selective glycogen synthase kinase 3 (GSK-3) inhibitor (IC50=104 nM). Inhibits beta-amyloid-mediated neurodegeneration in hippocampal slices. Antiinflammatory activity. Cell permeable. Active in rodent models.

References:


1. R Bhat et al. J. Biol. Chem. 2003 278: 45937

2. SH Ramirez et al. Am. J. Pathol. 2010 176:881


CAS Registry Number:

487021-52-3


Molecular Formula:

C12H12N4O4S


Appearance:

Off white powder


Melting Point:

N/A


Molecular Weight:

308.3


Purity:

>98% (TLC); NMR (Conforms)


Solubilization:

May be dissolved in DMSO (30 mg/ml)


Aliases:

N-[(4-Methoxyphenyl) methyl]-N'-(5-nitro-2-thiazolyl) urea


Storage and Stability:

Store desiccated as supplied at 4oC for up to 2 years. Store solutions at -20°C for up to 2 months.


Molecular Structure:



Product Datasheets



There are no related publications available for this product.


RESEARCH AREAS

AKT/PKB Pathway, Apoptosis/Autophagy, Cancer, Cardiovascular Disease, Inflammation, Invasion/Metastasis, Metabolic Disorder, Neurobiology, NfkB Pathway, WNT Signaling



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