Home    >   Kinase Inhibitors

Regorafenib

Multi-kinase inhibitor (Including KDR-Tie2)
Catalog No. K01-900


For enquiry on all Kinase Inhibitors email us at orders@signalchem.com


Catalog No. Pack Size Price (USD)
K01-900-05 5 mg $83
K01-900-25 25 mg $303
K01-900-BULK BULK Contact Us  


Overview:

A multi-kinase inhibitor related to sorafenib1. Inhibits c-Raf, B-Raf, VEGFR1, VEGFR2, VEGFR3, Tie2, PDGFRβ; FGFR1, c-Kit, and RET with IC50s=2.5, 28, 13, 4.2, 46, 311, 22, 202, 7 and 1.5 nM respectively1-2

References:


1. SM Wilhelm et al. Int. J. Cancer 2011 129:245

2. JCM Uitdehaag et al. PLoS One 2014 9(3):e92146


CAS Registry Number:

755037-03-7


Molecular Formula:

C21H15ClF4N4O3


Appearance:

Off-White powder


Molecular Weight:

482.80


Purity:

>98% (HPLC,TLC); NMR (conforms)


Solubilization:

May be dissolved in DMSO (50 mg/ml)


Aliases:

4-[4-[[[[4-chloro-3-(trifluoromethyl)phenyl]amino]carbonyl]amino]-3-fluorophenoxy]-N-methyl-2-pyridinecarboxamide; BAY 73-4506


Storage and Stability:

Store desiccated as supplied at -20oC for up to 2 year. Store solutions at -20oC for up to 3 months.


Molecular Structure:



Product Datasheets



There are no related publications available for this product.


RESEARCH AREAS

AKT/PKB Pathway, Angiogenesis, Apoptosis/Autophagy, Cancer, Cardiovascular Disease, ERK/MAPK Pathway, Inflammation, p38 Pathway, Receptor Tyrosine Kinases


RELATED PRODUCTS


  KDR, Active, K01-11G


SIGNALCHEM BIOTECH INC.


About

Terms of Service

Privacy Policy

Get the latest resources, updates and offers in your inbox