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Ruxolitinib

JAK1 and 2 Inhibitor
Catalog No. J01-901


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Catalog No. Pack Size Price (USD)
J01-901-05 5 mg $83
J01-901-25 25 mg $303
J01-901-BULK BULK Contact Us  


Overview:

Potent and selective JAK1&2 inhibitor, IC50s=2.7, 4.5 and 322 nM forJAK1, JAK2 and JAK3 respectively1. Blocks IL-6 signaling (IC50=281 nM) and proliferation of JAK2V617F+ Ba/F3 cells (IC50=127 nM)2. Inhibits the proinflammatory secretome of senescent cells3. The JAK1 S646P mutant is highly sensitive to ruxolitinib4. Clinically useful anticancer agent.

References:


1. S Verstovsek et al. Hematol. Am. Soc. Hematol. Educ. Program 2009 2009(1)636

2. A Quintas-Cardama et al. Blood 2010 115:3109

3. JN Farr et al. Nat. Med. 2017 23:1072

4. Q Li et al. Oncotarget 2017 8:34687


CAS Registry Number:

941678-49-5


Molecular Formula:

C17H18N6


Appearance:

White powder


Molecular Weight:

306.4


Purity:

>98% (HPLC,TLC); NMR (conforms)


Solubilization:

May be dissolved in DMSO (28 mg/ml) or ethanol (15 mg/ml warm)


Aliases:

(3R)-3-cyclopentyl-3-[4-(7H-pyrrolo[2,3-d]pyrimidin-4-yl)pyrazol-1-yl]propanenitrile


Storage and Stability:

Store desiccated as supplied at -20oC for up to 2 year. Store solutions at -20oC for up to 3 months.


Molecular Structure:



Product Datasheets



There are no related publications available for this product.


RESEARCH AREAS

Cancer, Cardiovascular Disease, Cytoplasmic Tyrosine Kinases, Inflammation, JAK/STAT Pathway


RELATED PRODUCTS


  JAK1 (R724H), Active, J01-12BG

  JAK1, Active, J01-11G

  JAK2, Active, J02-11G

  JAK3, Active, J03-11G


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