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Lenvatinib

Inhibitor of KDR (VEGFR2)
Catalog No. K01-901


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Catalog No. Pack Size Price (USD)
K01-901-05 5 mg $83
K01-901-25 25 mg $303
K01-901-BULK BULK Contact Us  


Overview:

A potent inhibitor of VEGFR2 and R3, IC50s=4.0 and 5.2 nM respectively1. Also inhibits VEGFR1, FGFR1, PDGFR3b and Kit, IC50s=22, 46, 39 and 100 nM respectively1.

References:


1. J Matsui et al. Int. J. Cancer. 2008 122:664


CAS Registry Number:

417716-92-8


Molecular Formula:

C21H19ClN4O4


Appearance:

white powder


Molecular Weight:

426.90


Purity:

>98% (TLC); NMR (conforms)


Solubilization:

May be dissolved in DMSO (20 mg/ml)


Aliases:

4-[3-Chloro-4-[[(cyclopropylamino)carbonyl]amino]phenoxy]-7-methoxy-6-quinolinecarboxamide; E7080


Storage and Stability:

Store desiccated as supplied at -20oC for up to 2 years. Store solutions at -20oC for up to 3 months.


Molecular Structure:



Product Datasheets



There are no related publications available for this product.


RESEARCH AREAS

AKT/PKB Pathway, Angiogenesis, Apoptosis/Autophagy, Cancer, Cardiovascular Disease, ERK/MAPK Pathway, Inflammation, p38 Pathway, Receptor Tyrosine Kinases


RELATED PRODUCTS


  KDR, Active, K01-11G


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