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KU-55933

ATM kinase inhibitor
Catalog No. A26-901


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Catalog No. Pack Size Price (USD)
A26-901-05 5 mg $83
A26-901-25 25 mg $325
A26-901-BULK BULK Contact Us  


Overview:

Potent and selective ATM kinase inhibitor IC50s= 13, 2500, 9300, 16600, >100000 and >100000 nM for ATM, DNA-PK, mTOR, PI 3-kinase, PI 4-K and ATR respectively1. Decreases viability of MCF-7, A549 and HCT116 cells and decreases p21CIP1 levels in vitro2.

References:


1. I Hickson et al. Cancer Res. 2004 64:9152

2. E Crescenzi et al. Clin. Cancer Res. 2008 14:1877


CAS Registry Number:

587871-26-9


Molecular Formula:

C21H17NO3S2


Appearance:

Tan powder


Molecular Weight:

395.50


Purity:

>98% (TLC); NMR (conforms)


Solubilization:

May be dissolved in DMSO (40 mg/ml); or ethanol (20 mg/ml)


Aliases:

2-(4-Morpholinyl)-6-(1-thianthrenyl)-4H-pyran-4-one


Storage and Stability:

Store desiccated as supplied at -20oC for up to 2 years. Store solutions at -20oC for up to 1 months.


Molecular Structure:



Product Datasheets



There are no related publications available for this product.


RESEARCH AREAS

Apoptosis/Autophagy, Cancer, Cardiovascular Disease, Cell Cycle, Cellular Stress, Inflammation, Lipid Kinases, Metabolic Disorder, Ser/Thr Kinases



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