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Ro 31-6045

Protein Kinase p70 (S6K) inhibitor
Catalog No. R21-901


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Catalog No. Pack Size Price (USD)
R21-901-1 1 mg $83
R21-901-05 5 mg $248
R21-901-BULK BULK Contact Us  


Overview:

This bis indolylmaleimide derivative is a potent inhibitor of the mitogen-stimulated protein kinase p70 (S6K) acting independently of its upstream activator mTOR1. Does not inhibit PKC (at concentrations <100 µM) and therefore may also be used as a negative control for bisindolylmaleimide PKC inhibitors2 such as GF 109203X3 and other structurally related inhibitors4

References:


1. N Marmy-Conus et al. FEBS Lett. 2002 519:135

2. CS Harmon et al. Skin Pharmacol. 1997 10:71

3. D Toullec et al. J. Biol. Chem. 1991 266:15771

4. PD Davis et al. J. Med. Chem. 1992 35:177


CAS Registry Number:

113963-68-1


Molecular Formula:

C21H15N3O2


Appearance:

Orange powder


Molecular Weight:

341.4


Purity:

>98% (HPLC, TLC); NMR (conforms)


Solubilization:

May be dissolved in DMSO (35 mg/ml); or ethanol (9 mg/ml)


Aliases:

1-Methyl-3,4-bis(indol-3-yl)maleimide; Bisindolylmaleimide V; BIM V


Storage and Stability:

Store desiccated as supplied at -20oC for up to 2 years. Store solutions at -20oC for up to 3 months.


Molecular Structure:



Product Datasheets



There are no related publications available for this product.


RESEARCH AREAS

AKT/PKB Pathway, Angiogenesis, Apoptosis/Autophagy, Cancer, Cardiovascular Disease, Inflammation, Metabolic Disorder, Ser/Thr Kinases


RELATED PRODUCTS


  p70S6K, Active, R21-10H

  p70S6Kb, Active, R22-10G


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