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Dabrafenib

B-Raf(mutant V600E) inhibitor
Catalog No. B08-901


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Catalog No. Pack Size Price (USD)
B08-901-05 5 mg $61
B08-901-25 25 mg $215
B08-901-BULK BULK Contact Us  


Overview:

Selective inhibitor of mutant B-RafV600E (IC50 = 0.8 nM), with 4- and 6-fold reduced potency against wild type B-Raf and c-Raf (IC50 = 3.2 and 5 nM, respectively)1 Has been in clinical trials in patients with B-RafV600E metastatic melanoma and other solid tumors.

References:


1. J Huang et al. J. Hematol. Oncol. 2013 6:1

2. C Ji et al. Drug Des. Dev. Ther. 2016 10:2491

3. R Herr et al. Cancer Res. 2015 75:216


CAS Registry Number:

1195765-45-7


Molecular Formula:

C23H20F3N5O2S2


Appearance:

Off-white powder


Molecular Weight:

519.6


Purity:

>98% (TLC); NMR (conforms)


Solubilization:

May be dissolved in DMSO (30 mg/ml); or ethanol (1 mg/ml, warm)


Aliases:

N-[3-[5-(2-amino-4-pyrimidinyl)-2-(1,1-dimethylethyl)-4-thiazolyl]-2-fluorophenyl]-2,6-difluoro-benzenesulfonamide; GSK2118436


Storage and Stability:

Store desiccated as supplied at -20oC for up to 1 year. Store solutions at -20oC for up to 3 months.


Molecular Structure:



Product Datasheets



There are no related publications available for this product.


RESEARCH AREAS

Angiogenesis, Apoptosis/Autophagy, Cancer, ERK/MAPK Pathway, JAK/STAT Pathway, Ser/Thr Kinases


RELATED PRODUCTS


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  BRAF (L597V), Active, B08-12HG

  BRAF (T599_V600insT), Active, B08-13BG


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