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TG003

CLK family Inhibitor
Catalog No. C57-901


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Catalog No. Pack Size Price (USD)
C57-901-05 5 mg $105
C57-901-25 25 mg $402
C57-901-BULK BULK Contact Us  


Overview:

Potent, ATP-competitive inhibitor of Clk-family kinases (IC50s = 15, 20 and 200 nM for mClk4, 1 and 2 respectively and >10 µM for mClk3)1. Also inhibits DYRK1A/B (IC50s = 24 and 34 nM respectively)2.

References:


1. J Bain M Muraki et al. J. Biol. Chem. 2004 279:24246

2. A Foucourt et al. Molecules 2014 19:15411

3. S A Nishida et al. Nat. Commun. 2011 2:308


CAS Registry Number:

719277-26-6


Molecular Formula:

C13H15NO2S


Appearance:

light yellow powder


Molecular Weight:

249.33


Purity:

>98% (HPLC); NMR (Conforms)


Solubilization:

May be dissolved in DMSO (20 mg/ml); or ethanol (15 mg/ml)


Aliases:

(Z)-1-(3-Ethyl-5-methoxy-2,3-dihydrobenzothiazol-2-ylidene)propan-2-one


Storage and Stability:

Store desiccated as supplied at 4oC temperature for up to 2 years. Store solutions at -20oC for up to 2 months.


Molecular Structure:



Product Datasheets



There are no related publications available for this product.


RESEARCH AREAS

Cancer, Cardiovascular Disease, Cell Cycle, Ser/Thr Kinases


RELATED PRODUCTS


  CLK1, Active, C57-11G

  CLK2, Active, C58-11G

  CLK3, Active, C60-10G

  CLK4, Active, C61-11G


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