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LY-364947

ALK5 Inhibitor
Catalog No. T07-901


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Catalog No. Pack Size Price (USD)
T07-901-05 5 mg $83
T07-901-25 25 mg $303
T07-901-BULK BULK Contact Us  


Overview:

Selective ALK5 inhibitor, IC50=59, 400 and 1400 nM for TGF-β RI, TGF-β RII and MLK-7K, respectively1. Inhibits Smad2 phosphorylation induced by TGF-β as well as fibronectin expression and MDA-MB-231 cell invasion2.

References:


1. JS Sawyer et al. J. Med. Chem. 2003 46:3953

2. SR Shiou et al. J. Biol. Chem. 2006 281:33971

3. ME Hardee et al. Cancer Res. 2012 72:4119


CAS Registry Number:

396129-53-6


Molecular Formula:

C17H12N4


Appearance:

Brown Powder


Molecular Weight:

272.31


Purity:

>98% (TLC); NMR (Conforms)


Solubilization:

May be dissolved in DMSO (25 mg/ml)


Aliases:

4-(3-Pyridin-2-yl-1H-pyrazol-4-yl)quinolone; HTS-466284


Storage and Stability:

Store desiccated as supplied at ambient temperature for up to 2 year. Store solutions at -20oC for up to 3 months.


Molecular Structure:



Product Datasheets



There are no related publications available for this product.


RESEARCH AREAS

AKT/PKB Pathway, Angiogenesis, Cancer, Cell Cycle, Cellular Stress, ERK/MAPK Pathway, Inflammation, JAK/STAT Pathway, JNK/SAPK Pathway, NfkB Pathway, Ser/Thr Kinases, WNT Signaling


RELATED PRODUCTS


  TGFBR1 (T204D), Active, T07-13G

  TGFBR1 (ALK5), Active, T07-11G

  TGFBR1 (ALK5), Active, T07-11BG


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