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7-CL-O-Nec-1

RIPK1 Inhibitor
Catalog No. R07-901B


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Catalog No. Pack Size Price (USD)
R07-901B-05 5 mg $105
R07-901B-25 25 mg $402
R07-901B-BULK BULK Contact Us  


Overview:

A necrostatin-1 analog with superior potency2, selectivity3 and metabolic stability at RIP1 inhibition (IC50 = 206 vs 494 nM)1,2.

References:


1. A Degterev et al. Nat. Chem. Biol. 2005 1:112

2. X Teng et al. Bioorg. Med. Chem. Lett. 2005 15:5039

3. N Takahashi et al. Cell Death Dis. 2012 3:e437


CAS Registry Number:

852391-15-2


Molecular Formula:

C13H12ClN3O


Appearance:

yellow powder


Molecular Weight:

277.71


Purity:

>98% (TLC); NMR (Conforms)


Solubilization:

May be dissolved DMSO (25 mg/ml)


Aliases:

Nec-1s; 5-((7-Chloro-1H-indol-3-yl)methyl)-3-methylimidazolidine-2,4-dione


Storage and Stability:

Store desiccated as supplied at ambient temperature for up to 2 years. Store solutions at -20oC for up to 3 months.


Molecular Structure:



Product Datasheets



There are no related publications available for this product.


RESEARCH AREAS

Apoptosis/Autophagy, Cancer, Inflammation, JAK/STAT Pathway, JNK/SAPK Pathway, p38 Pathway, Ser/Thr Kinases


RELATED PRODUCTS


  RIPK1, Active, R07-10G

  RIPK1, Active, R07-11G

  RIPK1, Active, R07M-11G

  RIPK1, Active, R07C-11G


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