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JX-401

p38a MAP kinase inhibitor
Catalog No. M39-901


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Catalog No. Pack Size Price (USD)
M39-901-10 10 mg $149
M39-901-50 50 mg $578
M39-901-BULK BULK Contact Us  


Overview:

Potent and selective p38α MAP kinase inhibitor XYZ XYZ (IC50=32 nM). Does not inhibit p38γ up to 10 μM. Inhibition is reversible and noncompetitive with ATP and substrate. Reversibly inhibits myoblast differentiation. Cell permeable.

References:


1. Y Friedmann et al. Mol. Pharmacol. 2006 70:1395


CAS Registry Number:

349087-34-9


Molecular Formula:

C21H25NO2S


Appearance:

Off-white solid


Melting Point:

204-206oC


Molecular Weight:

355.5


Purity:

>98% (TLC); NMR (Conforms)


Solubilization:

May be dissolved in DMSO (20 mg/ml); or Ethanol (10 mg/ml)


Aliases:

1-[2-Methoxy-4-(methylthio) benzoyl]-4-(phenylmethyl) piperidine


Storage and Stability:

Store desiccated as supplied at ambient temperature for up to 1 year. Store solutions at -20°C for up to 3 months.


Molecular Structure:



Product Datasheets



There are no related publications available for this product.


RESEARCH AREAS

Angiogenesis, Apoptosis/Autophagy, Cardiovascular Disease, Cellular Stress, Inflammation, Metabolic Disorder, Neurobiology, NfkB Pathway, p38 Pathway, Ser/Thr Kinases



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