Recombinant full-length human CDK1 was expressed by baculovirus in Sf9 insect cells using an N-terminal GST tag.
Catalog No. C22-14G
| Catalog No. | Pack Size | Price (USD) | |
|---|---|---|---|
| C22-14G-20 | 20 ug | $215 | |
| C22-14G-50 | 50 ug | $435 | |
| C22-14G-BULK | BULK | Contact Us |
Overview:
CDK1 or Cell Division Control protein 1 is essential for the completion of START, the controlling event in the cell cycle that is required to initiate mitosis. CDK1 is a catalytic subunit of a protein kinase complex, called the M-Phase Promoting Factor that induces entry into mitosis and is universal among eukaryotes (1). Phosphorylation of Bcl-2 in G2/M phase-arrested cells following photodynamic therapy with hypericin involves a CDK1-mediated signal and delays the onset of apoptosis. Therapeutic potential of CDK inhibitor NU2058 in androgen-independent prostate cancer has also been demonstrated (2).
Gene Aliases:
CDC2
Genbank Number:
References:
1. Vantieghem, A. et al: Phosphorylation of Bcl-2 in G2/M phase-arrested cells following photodynamic therapy with hypericin involves a CDK1-mediated signal and delays the onset of apoptosis. J. Biol. Chem. 2002; 277(40):37718-31.
2. Rigas, A.C. et al: Therapeutic potential of CDK inhibitor NU2058 in androgen-independent prostate cancer. Oncogene. 2007; 18.
Purity:
Sample Purity Data. For specific information on a given lot, see related technical data sheet.
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Storage, Stability and Shipping:
Store product at –70oC. For optimal storage, aliquot target into smaller quantities after centrifugation and store at recommended temperature. For most favorable performance, avoid repeated handling and multiple freeze/thaw cycles.
Molecular Weight:
~58 kDa
Ruiz Josue E et al., Meiotic Inactivation of Xenopus Myt1 by CDK/XRINGO, but Not CDK/Cyclin, via Site-Specific Phosphorylation Molecular Cell October 2008 10.1016/j.molcel.2008.08.029
Bury M et al., NFE2L3 Controls Colon Cancer Cell Growth through Regulation of DUX4, a CDK1 Inhibitor Cell Reports November 2019 10.1016/j.celrep.2019.09.087
M Kanke et al., Cohesin acetylation and Wapl-Pds5 oppositely regulate translocation of cohesin along DNA. EMBO Journal November 2016 10.15252/embj.201695756
Yang Shuping et al., CDK1 Phosphorylation of YAP Promotes Mitotic Defects and Cell Motility and Is Essential for Neoplastic Transformation Cancer Research November 2013 10.1158/0008-5472.CAN-13-2049
X Chen et al., MST2 phosphorylation at serine 385 in mitosis inhibits its tumor suppressing activity Cell Signal December 2016 10.1016/j.cellsig.2016.08.013
K Zhu et al., Phospho-Pon Binding-Mediated Fine-Tuning of Plk1 Activity. Structure May 2016 10.1016/j.str.2016.04.012
X Chen et al., Ajuba Phosphorylation by CDK1 Promotes Cell Proliferation and Tumorigenesis. Journal of Biological Chemistry July 2016 10.1074/jbc.M116.722751
Zhao Yulei et al., Regulation of sensitivity of tumor cells to antitubulin drugs by Cdk1-TAZ signalling Oncotarget May 2015 10.18632/oncotarget.4259
Dachineni Rakesh et al., Salicylic acid metabolites and derivatives inhibit CDK activity: Novel insights into aspirin's chemopreventive effects against colorectal cancer Int J Oncol. October 2017 10.3892/ijo.2017.4167
Bhandaria Deepali et al., Cyclin-dependent kinase 5 activates guanine nucleotide exchange factor GIV/Girdin to orchestrate migration?proliferation dichotomy PNAS July 2015 10.1073/pnas.1514157112
et al., Cyclin-dependent kinase 1 (CDK1)-mediated mitotic phosphorylation of the transcriptional co-repressor Vgll4 inhibits its tumor-suppressing activity The Journal of Biological Chemistry September 2017
et al., LIMD1 phosphorylation in mitosis is required for mitotic progression and its tumor-suppressing activity. The FEBS journal December 2019
et al., CDK1 phosphorylation of TAZ in mitosis inhibits its oncogenic activity Oncotarget October 2015
Cancer, Cell Cycle, Ser/Thr Kinases
CDK9/CyclinK, Active, C40-10G
Anti-CDC25A, C04-63R
CDK7, Unactive, C36-14G
CDK11B (CDC2L1), Unactive, C23-30G
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