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IRS1 (N-Term) Protein

Recombinant human IRS1 (1-355) was expressed in E. coli cells using an N-terminal GST tag.
Catalog No. I40-35G


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Catalog No. Pack Size Price (USD)
I40-35G-50 50 ug $435
I40-35G-20 20 ug $215
I40-35G-BULK BULK Contact Us  


Overview:

IRS1 is the substrate for the insulin tyrosine kinase receptor and is found in a variety of insulin-responsive cells and tissues. IRS1 protein has no intrinsic enzymatic activity but acts as a docking protein, via the SH2 domains, for mediating the insulin downstream signaling events. IRS1 has been shown to associate with the 14-3-3 family of proteins and this could play a role in the regulation of insulin sensitivity by interrupting the association between the insulin receptor and IRS1 (1). IRS1 may be associated with colorectal cancer and diet and related factors may affect the risk by modifying plasma insulin levels. Thus, the inter-individual variation in insulin signaling mediated by IRS1 may play a plausible role in the development of colorectal cancer (2).


Gene Aliases:

HIRS-1


Genbank Number:


References:


1. Ogihara, T. et al: 14-3-3 protein binds to insulin receptor substrate-1, one of the binding sites of which is in the phosphotyrosine binding domain. J. Biol. Chem. 272: 25267-25274, 1997.

2. Slattery, M.L. et al: Genetic variation in IGF1, IGFBP3, IRS1, IRS2 and risk of breast cancer in women living in Southwestern United States. Breast Cancer Res Treat. 2007;


Purity:

Sample Purity Data. For specific information on a given lot, see related technical data sheet.


Storage, Stability and Shipping:

Store product at –70oC. For optimal storage, aliquot target into smaller quantities after centrifugation and store at recommended temperature. For most favorable performance, avoid repeated handling and multiple freeze/thaw cycles.


Molecular Weight:

~65 kDa



Product Datasheets



RESEARCH AREAS

AKT/PKB Pathway, Cancer, Cellular Stress, ERK/MAPK Pathway


RELATED PRODUCTS


  14-3-3 alpha/beta Protein, Y71-30G

  14-3-3 alpha/beta Protein, Y71-30N

  14-3-3 zeta Protein, Y92-30N

  IRS1 (Y608) Peptide, I40-58


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