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MARK1, Active

Recombinant full-length human MARK1 was expressed by baculovirus in Sf9 insect cells using an N-terminal GST tag.
Catalog No. M43-10G


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Catalog No. Pack Size Price (USD)
M43-10G-05 5 ug $226
M43-10G-10 10 ug $325
M43-10G-BULK BULK Contact Us  


Overview:

MARK1 is a member of the MARK family and is a serine/threonine-protein kinase that plays a key role in signal transduction. Due to its protein serine/threonine kinase activity, MARK1 is known to mediate phosphorylation of key proteins involved in signal transduction and cell communication. MARK1 phosphorylates microtubule-associated proteins and trigger microtubule disruption (1). Gene mutation studies performed in mice revealed that after targeted disruption of the MARK1 gene, the mice lacked the ability to drink, and displayed hind leg motor dysfunction (2).


Gene Aliases:

MARK, KIAA1477


Genbank Number:


References:


1. Drewes, G. et al: MARK, a novel family of protein kinases that phosphorylate microtubule-associated proteins and trigger microtubule disruption. Cell 1997; 89:297-308.
2. Manabu, N. et al: A gene-targeting approach for functional characterization of KIAA genes encoding extremely large proteins. The FASEB Journal. 2006; 20:1718-1720.


Specific Activity:

Sample Kinase Activity Plot. For specific information on a given lot, see related technical data sheet.


Purity:

Sample Purity Data. For specific information on a given lot, see related technical data sheet.


Storage, Stability and Shipping:

Store product at –70oC. For optimal storage, aliquot target into smaller quantities after centrifugation and store at recommended temperature. For most favorable performance, avoid repeated handling and multiple freeze/thaw cycles.


Molecular Weight:

~125 kDa



There are no related publications available for this product.


RESEARCH AREAS

Invasion/Metastasis, Neurobiology, Ser/Thr Kinases


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