Overview:

RANGAP1, Ran GTPase activating protein 1, is the control substrate, which produces a single SUMO modification during SUMOylation (1). As a GTPase activator, RANGAP1 is involved in nuclear envelope assembly and nuclear transport through interacting with Ras-related nuclear protein 1(RAN) and regulating GTP-binding and exchange (2). Also, abnormal localization of RanGAP1 was found in cortex of the patients with Huntington’s disease (3)

Gene Aliases:

Fug1; RANGAP; SD

Genbank Number:

NM_002883

References:

1. Joseph J., et.al. SUMO-1 targets RanGAP1 to kinetochores and mitotic spindles. J. Cell Biol. 156:595-602, 2002.

2. Swaminathan S., et.al. RanGAP1*SUMO1 is phosphorylated at the onset of mitosis and remains associated with RanBP2 upon NPC disassembly. J. Cell Biol. 164:965-971, 2004.

3. Gasset-Rosa F., et.al. Polyglutamine-Expanded Huntingtin Exacerbates Age-Related Disruption of Nuclear Integrity and Nucleocytoplasmic Transport. Neuron. Apr 5; 94 (1):48-57, 2017.