Overview:

UBE2V2 or ubiquitin-conjugating enzyme E2 variant 2 constitutes a distinct subfamily within the E2 protein family which is critical for the catalytic activity of E2s and also shares homology with ubiquitin-conjugating enzyme E2 variant 1 and yeast MMS2 gene product. UBE2V2 may be involved in the differentiation of monocytes and enterocytes (1). UBE2V2 functions in assembly of novel polyubiquitin chains for DNA repair (2).

Gene Aliases:

DDVit-1; DDVIT1; EDAF-1; EDPF1; MMS2; UEV-2; UEV2

Genbank Number:

NM_003350

References:

1. Fritsche, J.et.al: Molecular cloning of a 1-alpha,25-dihydroxyvitamin D3-inducible transcript (DDVit 1) in human blood monocytes. Biochem. Biophys. Res. Commun. 235: 407-412, 1997.

2. Hofmann, R. M.et.al: Noncanonical MMS2-encoded ubiquitin-conjugating enzyme functions in assembly of novel polyubiquitin chains for DNA repair. Cell 96: 645-653, 1999.