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CLK3, Active

Recombinant full-length human CLK3 was expressed by baculovirus in Sf9 insect cells using an N-terminal GST tag.
Catalog No. C60-10G


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Catalog No. Pack Size Price (USD)
C60-10G-05 5 ug $226
C60-10G-10 10 ug $325
C60-10G-BULK BULK Contact Us  


Overview:

CLK3, also known as CDC-like kinase 3, encodes a serine/threonine type protein kinase with a non-conserved N-terminal domain. A long and short isoform (phclk3 and pclk3/152) result from alternative splicing and coexist in different tissues (1). The CLK3 protein has the molecular functions of ATP binding, nucleotide binding, protein serine/threonine kinase activity, protein-tyrosine kinase activity and transferase activity and the CLK3 protein localize in both the cytoplasm and nuclear compartment. CLK3 is thought to regulate the intranuclear distribution of the serine/arginine-rich (SR) family of splicing factors.


Gene Aliases:

PHCLK3, FLJ22858, PHCLK3/152


Genbank Number:


References:


1. Hanes, J. et al: , Characterization by cDNA cloning of two new human protein kinases. Evidence by sequence comparison of a new family of mammalian protein kinases". J. Mol. Biol. 1994; 244 (5): 665–72.


Specific Activity:

Sample Kinase Activity Plot. For specific information on a given lot, see related technical data sheet.


Purity:

Sample Purity Data. For specific information on a given lot, see related technical data sheet.


Storage, Stability and Shipping:

Store product at –70oC. For optimal storage, aliquot target into smaller quantities after centrifugation and store at recommended temperature. For most favorable performance, avoid repeated handling and multiple freeze/thaw cycles.


Molecular Weight:

~86 kDa



Product Datasheets



There are no related publications available for this product.


RESEARCH AREAS

Cancer, Cardiovascular Disease, Cell Cycle, Ser/Thr Kinases


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