Enzymes, Signaling Proteins, Extracellular Ligands, Signaling Reagents, Antibodies

Catalog No.	Pack Size	Price (USD)
K818-40N-10	10 ug	$193
K818-40N-1000	1 mg	$5473
K818-40N-BULK	BULK	Contact Us

Catalog No.

Pack Size

Price (USD)

K818-40N-10

10 ug

$193

K818-40N-1000

1 mg

$5473

K818-40N-BULK

BULK

Overview:

KGF is a member of the family of fibroblast growth factors, it is secreted in large amounts by fibroblast-like stromal cells in epithelial tissues. The KGF receptor encodes a tyrosine kinase and is a member of the family of receptors binding aFGF and bFGF. Binding of KGF to its receptor is competed by aFGF and bFGF. Although KGF is a potent specific mitogen for many epithelial cells it is not so for fibroblasts and endothelial cells. KGF is thought to play an important role in the paracrine growth control of normal epithelial cells. KGF stimulates the proliferation of primary and secondary human keratinocytes to the same extent as EGF.

Gene Aliases:

KGF, Fibroblast Growth Factor-7, HBGF-7, Heparin-binding growth factor 7, Recombinant Human Keratinocyte Growth Factor (FGF7)

Genbank Number:

P21781

Storage, Stability and Shipping:

The lyophilized protein is stable for at least one year from date of receipt at -70^oC. Upon reconstitution, this cytokine can be stored in working aliquots at 2^o - 8^oC for one month, or at -20^oC for six months, with a carrier protein without detectable loss of activity. Avoid repeated freeze/thaw cycles.

Endotoxin Level:

<1.0 EU/μg of recombinant protein as determined by the LAL method

Molecular Weight:

19.0 kDa

Reconstitution Protocol:

A quick spin of the vial followed by reconstitution in distilled water to a concentration not less than 0.1 mg/mL. This solution can then be diluted into other buffers.

Sample Cell Assay Data:

The ED50 as determined by the dose-dependent proliferation of 3T3 cells was found to be less than 0.5 ng/mL.