Recombinant Human TWEAK Receptor (TNFRSF12A) was expressed in E. coli cells.
Catalog No. T883-40N
| Catalog No. | Pack Size | Price (USD) | |
|---|---|---|---|
| T883-40N-25 | 25 ug | $275 | |
| T883-40N-100 | 100 ug | $850 | |
| T883-40N-1000 | 1 mg | $4995 | |
| T883-40N-BULK | BULK | Contact Us |
Overview:
Tumor necrosis factor receptor superfamily member 12A (TNFRSF12A) is the receptor for TNFSD12/TWEAK and is the smallest member of the TNF receptor superfamily. It is composed of a signal peptide, an extracellular domain, a membrane-anchoring domain, and a cytoplasmic “death” domain, which can activate a cell’s apoptotic mechanisms. It also promotes endothelial cell proliferation and angiogenesis, and modulates cellular adhesion to matrix proteins. TNFRSF12A expression can be found in the spleen, thymus, small intestine, and colon, and can be activated by membrane-anchored or soluble versions of TWEAK.
Gene Aliases:
Fibroblast growth factor-inducible immediate-early response protein 14, Tweak-receptor, CD-antigen: CD266
Genbank Number:
Storage, Stability and Shipping:
The lyophilized protein is stable for at least one year from date of receipt at -70oC. Upon reconstitution, this cytokine can be stored in working aliquots at 2o - 8oC for one month, or at -20oC for six months, with a carrier protein without detectable loss of activity. Avoid repeated freeze/thaw cycles.
Endotoxin Level:
<1.0 EU/μg of recombinant protein as determined by the LAL method
Molecular Weight:
5.6 kDa
Sample Cell Assay Data:
The ED50 is 2.0-12.0 µg/mL as determined by its ability to inhibit TWEAK-dependent proliferation in human umbilical vein endothelial cells (with use of 1 µg/mL rhTWEAK).
|
Purity:
Recombinant Human TWEAK Receptor (TNFRSF12A) resolved on a 10% SDS-PAGE gel under reducing conditions and stained with Coomassie Brilliant Blue G-250
|
There are no related publications available for this product.
Cancer, Cancer
STAY CONNECTED
Fax: 1-604-232-4601
Toll Free: 1-866-954-6273
info@signalchem.com