Recombinant Human CXCL14 (BRAK) was expressed in E. coli cells.
Catalog No. M842-40N
| Catalog No. | Pack Size | Price (USD) | |
|---|---|---|---|
| M842-40N-20 | 20 ug | $395 | |
| M842-40N-1000 | 1 mg | $7360 | |
| M842-40N-BULK | BULK | Contact Us |
Overview:
Chemokine (CXC motif) ligand 14, also known as breast and kidney-expressed chemokine (BRAK), is a CXC chemokine that is a potent chemoattractant for neutrophils but not for T-cells, B-cells, monocytes or granulocytes. Mature CXCL14 has many conserved features of the CXC family and is 30% homologous to the MIP-α and MIP-beta sequences, but differs in that it has an additional five amino acid sequence in between the third and fourth cysteines and a short N-terminus. It is usually highly expressed near its fibroblast source and in epidermal fibroblasts and keratinocytes of skin, but is absent from cancer cells.
Gene Aliases:
Chemokine BRAK, MIP-2G, Small-inducible cytokine B14.
Genbank Number:
Storage, Stability and Shipping:
The lyophilized protein is stable for at least one year from date of receipt at -70 oC. Upon reconstitution, this cytokine can be stored in working aliquots at 2o - 8oC for one month, or at -20oC for six months, with a carrier protein without detectable loss of activity. Avoid repeated freeze/thaw cycles.
Endotoxin Level:
<1.0 EU/μg of recombinant protein as determined by the LAL method.
Molecular Weight:
9.6 kDa
Reconstitution Protocol:
Reconstitute in sterile 4mM HCl at 100µg/mL (containing at least 0.1% human or bovine serum albumin).
Sample Cell Assay Data:
The ED50 is 0.25-1.25 ng/mL as determined by its ability to induce calcium flux in activated monocytes.
Purity:
Recombinant Human CXCL14 (BRAK) resolved on a 17% SDS-PAGE gel under reducing conditions and stained with Coomassie Brilliant Blue G-250.
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