Recombinant human LATS2 (480-1088) was expressed by baculovirus in Sf9 insect cells using an N-terminal GST tag.
Catalog No. L02-11G
| Catalog No. | Pack Size | Price (USD) | |
|---|---|---|---|
| L02-11G-05 | 5 ug | $226 | |
| L02-11G-10 | 10 ug | $325 | |
| L02-11G-BULK | BULK | Contact Us |
Overview:
LATS2 is a serine/threonine protein kinase belonging to the LATS tumor suppressor family. LATS2 interacts with a negative regulator of p53 and function in a positive feedback loop with p53 that responds to cytoskeleton damage and this interaction provokes centrosome/mitotic apparatus dysfunction (1). LATS2 plays an essential role in the maintenance of mitotic fidelity and genomic integrity (2).
Gene Aliases:
none
Genbank Number:
References:
1. Aylon, Y. et.al: A positive feedback loop between the p53 and Lats2 tumor suppressors prevents tetraploidization. Genes Dev. 20: 2687-2700, 2006.
2. McPherson, J. P. et.al: Lats2/Kpm is required for embryonic development, proliferation control and genomic integrity. EMBO J. 23: 3677-3688, 2004.
Specific Activity:
Sample Kinase Activity Plot. For specific information on a given lot, see related technical data sheet.
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Purity:
Sample Purity Data. For specific information on a given lot, see related technical data sheet.
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Storage, Stability and Shipping:
Store product at –70oC. For optimal storage, aliquot target into smaller quantities after centrifugation and store at recommended temperature. For most favorable performance, avoid repeated handling and multiple freeze/thaw cycles.
Molecular Weight:
~110 kDa
Meistermann Helene et al., A Novel Immuno-Competitive Capture Mass Spectrometry Strategy for Protein-Protein Interaction Profiling Reveals that LATS Kinases Regulate HCV Replication through NS5A Phosphorylation Molecular & Cellular Proteomics July 2014 10.1074/mcp.M113.028977
D Shao et al., A functional interaction between Hippo-YAP signalling and FoxO1 mediates the oxidative stress response. Nature Communications February 2014 10.1038/ncomms4315
Yang X et al., A kinome-wide screen using a NanoLuc LATS luminescent biosensor identifies ALK as a novel regulator of the Hippo pathway in tumorigenesis and immune evasion Faseb Journal August 2019 10.1096/fj.201901343R
et al., A LATS biosensor screen identifies VEGFR as a regulator of the Hippo pathway in angiogenesis Nature Communications March 2018
et al., Transcriptional repression of estrogen receptor alpha by YAP reveals the Hippo pathway as therapeutic target for ER + breast cancer Nature Communications February 2022
et al., LATS kinase–mediated CTCF phosphorylation and selective loss of genomic binding Science Advances February 2020
Apoptosis/Autophagy, Cancer, Cardiovascular Disease, Cell Cycle
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