Full-length recombinant human H11 (HSP22) was expressed by baculovirus in Sf9 insect cells using an N-terminal GST tag.
Catalog No. H09-34G
| Catalog No. | Pack Size | Price (USD) | |
|---|---|---|---|
| H09-34G-20 | 20 ug | $215 | |
| H09-34G-50 | 50 ug | $435 | |
| H09-34G-BULK | BULK | Contact Us |
Overview:
H11 or heat shock 22kDa protein 8 belongs to the superfamily of small heat-shock proteins containing a conservative alpha-crystallin domain at the C-terminal part of the molecule. The expression of H11 is induced by estrogen in estrogen receptor-positive breast cancer cells, and H11 also functions as a chaperone in association with Bag3, a stimulator of macroautophagy. H11 is involved in regulation of cell proliferation, apoptosis, and carcinogenesis (1). H11 also causes motor neuron-specific neurite degeneration (2).
Gene Aliases:
HSP22; CRYAC; CMT2L; DHMN2; E2IG1; HSPB8; HMN2; HMN2A; PP1629
Genbank Number:
References:
1. Benndorf, R.et.al: Shocking degeneration. Nature Genet. 36: 547-548, 2004.
2. Irobi, J.et.al: Mutant HSPB8 causes motor neuron-specific neurite degeneration. Hum. Molec. Genet. 19: 3254-3265, 2010.
Purity:
Sample Purity Data. For specific information on a given lot, see related technical data sheet.
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Storage, Stability and Shipping:
Store product at –70oC. For optimal storage, aliquot target into smaller quantities after centrifugation and store at recommended temperature. For most favorable performance, avoid repeated handling and multiple freeze/thaw cycles.
Molecular Weight:
~50 kDa
There are no related publications available for this product.
AKT/PKB Pathway, Apoptosis/Autophagy, Cardiovascular Disease, Cell Cycle, Metabolic Disorder, NfkB Pathway
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