Recombinant human KDM2A (1-748) was expressed by baculovirus in Sf9 insect cells using an N-terminal GST tag.
Catalog No. K422-31G
| Catalog No. | Pack Size | Price (USD) | |
|---|---|---|---|
| K422-31G-20 | 20 ug | $215 | |
| K422-31G-50 | 50 ug | $435 | |
| K422-31G-BULK | BULK | Contact Us |
Overview:
KDM2A or lysine (K)-specific demethylase 2A is a member of the F-box protein family that are components of the modular E3 ubiquitin protein ligases called SCFs (SKP1-cullin-F-box), which function in phosphorylation-dependent ubiquitination (1). KDM2A belongs to the Fbls class and, in addition to the presence of an F-box, contains at least six highly degenerated leucine-rich repeats which play a role in epigenetic silencing. The demethylase activity of the JmjC domain-containing proteins is conserved from yeast to human (2).
Gene Aliases:
CXXC8; FBL11; FBL7; FBXL11; JHDM1A; LILINA
Genbank Number:
References:
1. Cenciarelli, C.et.al: Identification of a family of human F-box proteins. Curr. Biol. 9: 1177-1179, 1999.
2. Tsukada, Y. et.al: Histone demethylation by a family of JmjC domain-containing proteins. Nature 439: 811-816, 2006.
Purity:
Sample Purity Data. For specific information on a given lot, see related technical data sheet.
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Storage, Stability and Shipping:
Store product at –70oC. For optimal storage, aliquot target into smaller quantities after centrifugation and store at recommended temperature. For most favorable performance, avoid repeated handling and multiple freeze/thaw cycles.
Molecular Weight:
~115 kDa
Cancer, Cell Cycle, Inflammation
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et al., Dismissal of RNA Polymerase II Underlies a Large Ligand-induced Enhancer Decommissioning Program Molecular cell August 2019 
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