Recombinant human HIPK3 (163-562) was expressed by baculovirus in Sf9 insect cells using an N-terminal His tag.
Catalog No. H05-13H
Catalog No. | Pack Size | Price (USD) | |
---|---|---|---|
H05-13H-05 | 5 ug | $226 | |
H05-13H-10 | 10 ug | $325 | |
H05-13H-BULK | BULK | Contact Us |
Overview:
HIPK3 (homeodomain interacting protein kinase 3) is a member of the HIPK family and is involved in apoptosis (1). JNK regulates the expression of HIPK3 in prostate cancer cells and this contributes to increased resistance to Fas receptor-mediated apoptosis by reducing the interaction between FADD and caspase-8 (2). HIPK3 has been reported to phosphorylate FADD and is implicated in multidrug resistance in a number of tumors. HIPK3 increases transcription factor SF-1 activity leading to increased steroidogenic gene expression in response to cAMP signaling.
Gene Aliases:
PKY, YAK1, DYRK6, FIST3
Genbank Number:
References:
1. Begley, D.A. et al:Identification and sequence of human PKY, a putative kinase with increased expression in multidrug-resistant cells, with homology to yeast protein kinase Yak1. Gene, 1997; 200 (1-2): 35–43.
2. Curtin, J F. et al: JNK regulates HIPK3 expression and promotes resistance to Fas-mediated apoptosis in DU 145 prostate carcinoma cells. J Biol Chem. 2004 Apr 23;279(17):17090-100.
Specific Activity:
Sample Kinase Activity Plot. For specific information on a given lot, see related technical data sheet.
Purity:
Sample Purity Data. For specific information on a given lot, see related technical data sheet.
Storage, Stability and Shipping:
Store product at –70oC. For optimal storage, aliquot target into smaller quantities after centrifugation and store at recommended temperature. For most favorable performance, avoid repeated handling and multiple freeze/thaw cycles.
Molecular Weight:
~49kDa
Cancer, Cell Cycle, Metabolic Disorder, Ser/Thr Kinases, WNT Signaling
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