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STAT6 Protein

Full-length recombinant human STAT6 was expressed in Sf9 insect cells using an N-terminal GST tag.
Catalog No. S57-30G


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Catalog No. Pack Size Price (USD)
S57-30G-50 50 ug $435
S57-30G-20 20 ug $215
S57-30G-BULK BULK Contact Us  


Overview:

The STAT6 protein is a member of the STAT family of transcription factors that are activated by cytokines and phosphorylated by the receptor associated kinases. STATs form homo- or hetero-dimers that translocate to the cell nucleus where they act as transcription activators (1). STAT6 plays a central role in exerting IL4 mediated biological responses. STAT6 induces the expression of BCL2L1/BCL-XL, which is responsible for the anti-apoptotic activity of IL4. STAT6 mRNA has been detected in various tissues including peripheral blood lymphocytes, colon, intestine, ovary, prostate, thymus, spleen, kidney, liver, lung and placenta. STAT6 is critically involved in Th2 immune response (2).


Gene Aliases:

STAT6B, STAT6C, D12S1644, IL-4-STAT


Genbank Number:


References:


1. Weidinger, S. et al: Association of a STAT 6 haplotype with elevated serum IgE levels in a population based cohort of white adults. J. Med. Genet. 41: 658-663, 2004.

2. Wang, W. et al: The susceptibility to experimental myasthenia gravis of STAT6-/- and STAT4-/- BALB/c mice suggests a pathogenic role of Th1 cells. J. Immun. 172: 97-103, 2004.


Purity:

Sample Purity Data. For specific information on a given lot, see related technical data sheet.


Storage, Stability and Shipping:

Store product at –70oC. For optimal storage, aliquot target into smaller quantities after centrifugation and store at recommended temperature. For most favorable performance, avoid repeated handling and multiple freeze/thaw cycles.


Molecular Weight:

~138 kDa



Product Datasheets



There are no related publications available for this product.


RESEARCH AREAS

Apoptosis/Autophagy, Cancer, ERK/MAPK Pathway, Inflammation, JAK/STAT Pathway


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