Recombinant full-length tag-free human Alpha-synuclein (A53T) Pre-Formed Fibrils (Type 1) was expressed in E. coli cells.
Catalog No. S22-361N
Catalog No. | Pack Size | Price (USD) | |
---|---|---|---|
S22-361N-100 | 100 ug | $455 | |
S22-361N-200 | 200 ug | $755 | |
S22-361N-500 | 500 ug | $1455 | |
S22-361N-BULK | BULK | Contact Us |
Overview:
Alpha-Synuclein (SNCA) is expressed predominantly in the brain, where it is concentrated in presynaptic nerve terminals (1). Alpha-synuclein is highly expressed in the mitochondria of the olfactory bulb, hippocampus, striatum and thalamus (2). Functionally, it has been shown to significantly interact with tubulin (3), and may serve as a potential microtubule-associated protein. It has also been found to be essential for normal development of the cognitive functions; inactivation may lead to impaired spatial learning and working memory (4). SNCA fibrillar aggregates represent the major non A-beta component of Alzheimers disease amyloid plaque, and a major component of Lewy body inclusions, and Parkinson's disease. Parkinson's disease (PD) is a common neurodegenerative disorder characterized by the progressive accumulation in selected neurons of protein inclusions containing alpha-synuclein and ubiquitin (5, 6). The A53T mutation is a missense point mutation where alanine is replaced by threonine at the 53rd amino acid. This mutation has been linked to early-onset Parkinson's Disease (7) and increased rates of alpha synuclein fibrillization (8).
Genbank Number:
References:
1. “Genetics Home Reference: SNCA”. US National Library of Medicine. (2013).
2. Zhang L., et al. (2008) Brain Res. 1244: 40-52.
3. Alim M.A., et al. (2002) J Biol Chem. 277(3): 2112-2117.
4. Kokhan V.S., Afanasyeva M.A., Van’kin G. (2012) Behav. Brain. Res. 231(1): 226-230.
5. Spillantini M.G., et al. (1997) Nature. 388(6645): 839-840.
6. Mezey E., et al. (1998) Nat Med. 4(7): 755-757.
7. Polymeropoulos, M. H. (1998). Science. 276(5321), 2045–2047
8. Conway, K.E., et al. (1998). Nat Med. 4(11):1318-20
Alternative Names:
A53T mutant alpha synuclein; A53T mutated SNCA; Non-A beta component of AD amyloid protein; Non-A4 component of amyloid precursor protein
Storage and Stability:
Store product at –70oC. For optimal storage, aliquot target into smaller quantities after centrifugation and store at recommended temperature. For most favorable performance, avoid repeated handling and multiple freeze/thaw cycles.
Sample Data:
TEM of Alpha Synuclein (A53T) Pre-Formed Fibrils (Type 1)
There are no related publications available for this product.
Neurobiology
STAY CONNECTED
Fax: 1-604-232-4601