UBE2B or ubiquitin-conjugating enzyme E2B is a member of the E2 ubiquitin-conjugating enzyme family which is required for post-replicative DNA damage repair. UBE2B is specifically important during chronic low-dose ultraviolet exposure to prevent counterproductive DNA checkpoint activation and allow cells to proliferate normally (1). The activity of UBE2B is required within the synaptonemal complex and for meiotic recombination in spermatocytes (2). Experimental inactivation of the UBE2B gene in mice causes male infertility.
E2-17kDa; HHR6B; HR6B; RAD6B; UBC2
1. Hishida, T. et.al: RAD6-RAD18-RAD5-pathway-dependent tolerance to chronic low-dose ultraviolet light. Nature 457: 612-615, 2009.
2. Baarends, W. M. et.al: Loss of HR6B ubiquitin-conjugating activity results in damaged synaptonemal complex structure and increased crossing-over frequency during the male meiotic prophase. Molec. Cell. Biol. 23: 1151-1162, 2003.
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Cancer, Cell Cycle, Cytoplasmic Tyrosine Kinases, Neurobiology