Home   >    Enzymes   >   Ubiquitin Enzymes

UBE2O, Active

Recombinant full-length human UBE2O was expressed by baculovirus in Sf9 insect cells using an N-terminal GST tag.
Catalog No. U232-380G


Shop Online



Catalog No. Pack Size Price (USD)
U232-380G-20 20 ug $215
U232-380G-50 50 ug $435
U232-380G-BULK BULK Contact Us  


Overview:

UBE2O or ubiquitin-conjugating enzyme E2O is a part of the ubiquitin-mediated protein degradation pathway in which a thiol-ester linkage forms between a conserved cysteine and the C-terminus of ubiquitin and complexes with ubiquitin. HIV-1 Tat has been identified to have a physical interaction with ubiquitin-conjugating enzyme E2O (UBE2O) in human HEK293 and Jurkat cell lines by using affinity tagging and purification mass spectrometry analyses.


Gene Aliases:

E2-230K, FLJ12878, KIAA1734


Genbank Number:


References:


1. Mondal, S. et al: A bioluminescent assay for monitoring conjugation of ubiquitin and ubiquitin-like proteins. Anal. Biochem. 510: 41-51, 2016

2. Zhang, X. et al: Fine-tuning BMP7 signalling in adipogenesis by UBE2O/E2-230K-mediated monoubiquitination of SMAD6. EMBO J. 32(7):996-1007, 2013

3. Mashtalir, N. et al: Autodeubiquitination protects the tumor suppressor BAP1 from cytoplasmic sequestration mediated by the atypical ubiquitin ligase UBE2O. Mol. Cell. 54(3):392-406, 2014


Specific Activity:

Sample Activity Plot. For specific information on a given lot, see related technical data sheet.


Purity:

Sample Purity Data. For specific information on a given lot, see related technical data sheet.


Storage, Stability, and Shipping:

Store product at –70oC. For optimal storage, aliquot target into smaller quantities after centrifugation and store at recommended temperature. For most favorable performance, avoid repeated handling and multiple freeze/thaw cycles.


Molecular Weight:

106 kDa



Product Datasheets



Safety Datasheet



There are no related publications available for this product.


RESEARCH AREAS

Cancer, Cell Cycle, Neurobiology


RELATED PRODUCTS


  UBA1 (UBE1), Active, U201-380G

  BIRC3, Active, B280-380G

  Ubiquitin Protein, U06-54N


SIGNALCHEM BIOTECH INC.


About

Terms of Service

Privacy Policy

Get the latest resources, updates and offers in your inbox