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UBE2D3 (UBCH5C), Active

Recombinant full-length human UBE2D3 was expressed in E. coli cells using an N-terminal His tag.
Catalog No. U215-380H


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Catalog No. Pack Size Price (USD)
U215-380H-20 20 ug $215
U215-380H-50 50 ug $435
U215-380H-BULK BULK Contact Us  


Overview:

UBE2D3 also known as UBCH5C or ubiquitin-conjugating enzyme E2D3 is a member of the E2 ubiquitin-conjugating enzyme family which is an important cellular mechanism for targeting abnormal or short-lived proteins for degradation. UBE2D3 is involved in RA-induced cell cycle arrest and as a mediator of all-trans retinoic acid-induced cell growth arrest in human acute promyelocytic NB4 cells. UBE2D3 functions in the ubiquitination of the tumor-suppressor protein p53, which is induced by an E3 ubiquitin-protein ligase and is critical for normal cellular, tissue, and organismal physiology.


Gene Aliases:

E2(17)KB3, UBC4/5, UBCH5C


Genbank Number:


References:


1. Mondal, S. et al: A bioluminescent assay for monitoring conjugation of ubiquitin and ubiquitin-like proteins. Anal. Biochem. 510: 41-51, 2016

2. Hattori, H. et al: RNAi screen identifies UBE2D3 as a mediator of all-trans retinoic acid-induced cell growth arrest in human acute promyelocytic NB4 cells. Blood 110: 640-650, 2007.

3. Hutt, D. et al: The proteome in balance. Science 329: 766-767, 2010


Specific Activity:

Sample Activity Plot. For specific information on a given lot, see related technical data sheet.


Purity:

Sample Purity Data. For specific information on a given lot, see related technical data sheet.


Storage, Stability, and Shipping:

Store product at –70oC. For optimal storage, aliquot target into smaller quantities after centrifugation and store at recommended temperature. For most favorable performance, avoid repeated handling and multiple freeze/thaw cycles.


Molecular Weight:

17 kDa



Product Datasheets



Safety Datasheet



There are no related publications available for this product.


RESEARCH AREAS

Cancer, Cell Cycle, Neurobiology


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