UBE2L6 (UBCH8) or ubiquitin-conjugating enzyme E2L 6 is a member of the E2 ubiquitin-conjugating enzyme family which is highly similar in primary structure to the enzyme encoded by the UBE2L3 gene. Ubiquitination involves at least three classes of enzymes: ubiquitin-activating enzymes (E1s), ubiquitin-conjugating enzymes (E2s) and ubiquitin-protein ligases (E3s) and the selective physical interaction between E2 and E3 enzymes forms the basis of specificity for functionally distinct E2-E3 combinations (1). UBE2L6 and the ubiquitin-ligase SIAH1 physically interact with and target FLT3-ITD for proteasomal degradation (2).
1. Kumar, S. et.al: Physical interaction between specific E2 and Hect E3 enzymes determines functional cooperativity. J. Biol. Chem. 272: 13548-13554, 1997.
2. Buchwald, M. et al: Ubiquitin conjugase UBCH8 targets active FMS-like tyrosine kinase 3 for proteasomal degradation. Leukemia. 2010 Aug; 24(8):1412-21.
Sample Activity Plot. For specific information on a given lot, see related technical data sheet.
Sample Purity Data. For specific information on a given lot, see related technical data sheet.
Storage, Stability, and Shipping :
Store product at –70oC. For optimal storage, aliquot target into smaller quantities after centrifugation and store at recommended temperature. For most favorable performance, avoid repeated handling and multiple freeze/thaw cycles.
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