Home   >    Proteins   >   Protein Kinases

PKC epsilon, Active

Recombinant full-length human PKCepsilon was expressed by baculovirus in Sf9 insect cells using a N-terminal GST tag.
Catalog No. P65-10G


Shop Online



Catalog No. Pack Size Price (USD)
P65-10G-05 5 ug $160
P65-10G-10 10 ug $226
P65-10G-BULK BULK Contact Us  


Overview:

PKCε is a member of the protein kinase C (PKC) family of serine- and threonine-specific protein kinases that can phosphorylate a wide variety of protein targets known to be involved in diverse cellular signaling pathways. PKCε is involved in many different cellular functions, such as neuron channel activation , cardioprotection from ischemia (1), heat shock response, as well as insulin exocytosis. Knockout studies in mice suggest that this kinase is important for lipopolysaccharide (LPS)-mediated signaling in activated macrophages and may control anxiety-like behavior (2).


Gene Aliases:

PRKCE; MGC125656; MGC125657; nPKC-epsilon


Genbank Number:


References:


1. Chen, C H. et al: Cardioprotection from ischemia by a brief exposure to physiological levels of ethanol: role of epsilon protein kinase C. Proc. Nat. Acad. Sci. 96: 12784-12789, 1999.

2. Hodge, C W. et al: Decreased anxiety-like behavior, reduced stress hormones, and neurosteroid supersensitivity in mice lacking protein kinase C-epsilon. J. Clin. Invest. 110: 1003-1010, 2002.


Specific Activity:

Sample Kinase Activity Plot. For specific information on a given lot, see related technical data sheet.


Purity:

Sample Purity Data. For specific information on a given lot, see related technical data sheet.


Storage, Stability and Shipping:

Store product at –70oC. For optimal storage, aliquot target into smaller quantities after centrifugation and store at recommended temperature. For most favorable performance, avoid repeated handling and multiple freeze/thaw cycles.


Molecular Weight:

~110 kDa



RESEARCH AREAS

Apoptosis/Autophagy, Cardiovascular Disease, ERK/MAPK Pathway, Neurobiology, NfkB Pathway, PKA/PKC Pathway, Ser/Thr Kinases


RELATED PRODUCTS


  PKC mu, Active, P72-10G

  PKC nu, Active, P73-10G

  PKC alpha, Active, P61-18G

  AMPK (A1/B1/G3), Active, P56-10H


SIGNALCHEM BIOTECH INC.


About

Terms of Service

Privacy Policy

Get the latest resources, updates and offers in your inbox